Seth Doege and No. 23 Texas Tech thought they'd never get beaten as badly as during a 60-point loss to Oklahoma State last season.
The rematch wasn't much better.
Isaiah Anderson had a career-best 174 yards receiving and caught three long touchdown passes from Clint Chelf in his final home game, leading Oklahoma State to a 59-21 win against the Red Raiders on Saturday.
Zack Craig blocked a pair of punts, returning one for a touchdown, as the Cowboys (7-3, 5-2 Big 12) won their fourth straight in the series and the second in a row in decisive fashion. The Red Raiders' 66-6 loss in last season's game was the most lopsided defeat in the program's history.
"Tough night for us," Tech coach Tommy Tuberville said. "We ran into a buzzsaw."
The Red Raiders had a chance to pass the defending conference champions in the Big 12 standings, and perhaps secure a better bowl destination, but instead dropped their fifth straight game in Stillwater in another blowout.
Doege threw for 230 yards with two interceptions and a single touchdown pass for Texas Tech (7-4, 4-4). He started the day leading the Bowl Subdivision with 34 touchdown passes this season.
The Red Raiders also turned it over on a snap over Doege's head and had twice as many penalty yards as Oklahoma State.
"Bad things just kept happening to us," said Tuberville, who didn't allow his players to speak to reporters.
Tuberville blamed some of the offensive issues on the loss of left tackle LaAdrian Waddle, the team's best offensive lineman, to an injury. Everything came unglued during the second quarter, when a series of big plays on defense and special teams sparked Oklahoma State to 28 consecutive points.
The Cowboys sacked Doege three times in the first half and Tyler Johnson was pressuring him again to force an ill-advised throw that Shamiel Gary intercepted. Just two plays later, Chelf connected with Anderson on a 33-yard flea flicker pass to push the Oklahoma State advantage to 21-7.
Tech couldn't respond and followed that by going three-and-out, with Craig rushing in to block Ryan Erxleben's punt and keep Oklahoma State's roll going. J.W. Walsh finished the ensuing drive with a 2-yard TD run on a quarterback keeper, and Chelf threw a 66-yard touchdown pass to Anderson on the first play after another Red Raiders three-and-out.
"No excuses. We didn't execute," Tuberville said. "But it didn't help us with our young inside guys, having to play those guys. They were trying to get everybody lined up and call the right front and making the calls and getting them on the right guys."
Chelf passed for 229 yards in his second career start. Walsh, who had what coach Mike Gundy called a season-ending injury four weeks ago, ran for one touchdown and threw for another out of a short-yardage package.
Anderson was on the receiving end of scoring passes of 60, 33 and 66 yards from Chelf and ended up with nearly three times his previous career-best of 64 yards receiving in a game.
Joseph Randle and Jeremy Smith each tacked on touchdown runs for Oklahoma State in the second half, and Quinn Sharp matched his career-long with a 51-yard field goal. Craig's punt block extended the lead to 59-14 early in the fourth quarter.
It wasn't the complete dominance as last season, when Oklahoma State was up 35-0 after the first quarter and 49-0 by halftime. But it wasn't far off.
"You're just trying to go out and win. It doesn't really matter how it happens," Chelf said. "They're a good team, but we came to play today with a lot of energy and wanted to send the seniors off right."
Doege threw a 2-yard TD pass to Tyson Williams with 15 seconds left before halftime, and the Red Raiders got the ball to start the second half. But Doege's second interception - directly into the arms of retreating defensive tackle James Castleman - ended that drive and any momentum for Tech.
Darrin Moore caught a late 7-yard touchdown pass from backup Michael Brewer and finished with 140 yards receiving for Texas Tech.
Since ending an unbeaten start by then-No. 5 West Virginia a month ago, the Red Raiders have lost three times and squeaked out a pair of wins in triple overtime and double overtime.
"I've got no problem with effort, how the guys go into each game and how they compete," Tuberville said. "It's just, it seems like we were our own worst enemy in a lot of ways tonight, in terms of just mentally not making a play, or mentally as a coach, putting a guy in a position to not have success. It's been a long eight games but we'll bounce back."